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Monday, September 25, 2006

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Welcome to Epidemiologic Inquiry. Please subscribe to our email list below for regular updates on new content (average less than 1 email per week). We look forward to informing readers about the latest outstanding studies in epidemiology and medicine, as well as insightful commentaries into new research and a rapid forum for scientific debate.

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~The Editors, Epidemiologic Inquiry


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NIH Grant Success Rates and Change from 2004, by NIH institutes FY2005

The figure below shows a summary of NIH research grant application awards and success rates by NIH institutes in 2005, as well as change in awards and success rates from 2004.

Overall, results indicate that overall grant success rate dropping by 2.3%, or an absolute grant award decrease by 453 funded projects and -$171 million.

[Click to image to enlarge]














Note: Success rates indicate the percentage of reviewed Research Project Grant applications that receive funding. Applications that have one or more amendments in the same fiscal year are only counted once. The total cost is the sum of the direct and indirect costs for each fiscal year, and not for the life of the project.

(Source: manually tabulated from NIH data by the Editor. Table available in Excel by request. Additionally success rate data by grant mechanism is available here)



 
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Sunday, September 17, 2006

Impact Factors of Genetics Journals

Below are 2005 journal IMPACT FACTORS for genetics journals. Visit here for general science and general clinical journal impact factors.

Genetics

Nature Genetics 25.8
Nature Rev Genetics 19.2
Genes Dev 15.6
Ann Rev Genetics 14.0
Am J Human Genetics 12.6
Trends Genetics 12.0
Ann Rev Genomics Human Genetics 10.1
Genome Res 10.1
Genome Biology 9.7
Curr Opin Genetics Dev 9.4
Human Mutation 7.9
Human Molecular Genetics 7.8
Oncogene 6.9
Molecular Biology Evol 6.2
Pharmacogenetics 5.9
Molecular Therapy 5.4
Mutation Res 5.3
Genetic Epidemiology 5.1
DNA Repair 5.0
Gene Therapy 4.8
J Mol Medicine (JMM) 4.7
BMC Evol Biology 4.4
Human Genetics 4.3
J Medical Genetics 4.3
Genetics 4.3
Am J Medical Genetics (Parts B and C) 4.3 and 3.5
Evolution 4.2
BMC Genomics 4.1
Human Gene Therapy 4.1
Pharmacogenomics J 4.0
DNA Res 3.9
Genes Immunity 3.8
J Gene Medicine 3.7
Human Heredity 3.6
Genes Cells 3.4
Clinical Genetics 3.3
Eur J Hum Genetics 3.3
Genetic in Medicine 3.1



 
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Impact Factors of Epidemiology and Public Health Journals

Below are 2005 journal IMPACT FACTORS for epidemiology and public health-related journals. Visit here for general science and general clinical journal impact factors.

Epidemiology & Public Health

American J Epidemiology 5.1
Genetic Epidemiology 5.1
Epidemiologic Reviews 4.7
Cancer Epidemiology Biomarkers Prevention 4.5
Epidemiology 4.0
International J Epidemiology 4.0
Ann Rev Public Health 3.7
Am J Public Health 3.6
Am J Preventive Medicine 3.2
J Epidemiology Comm Health 3.0
J Clinical Epidemiology 2.5
Infection Control Hospital Epidemiology 2.4
Annals of Epidemiology 2.3
Preventive Medicine 2.2
Public Health Nutrition 1.9
Paediatric Perinatal Epidemiology 1.8
Epidemiology and Infection 1.7
BMC Public Health 1.7
Public Health Reports 1.5
Eur J Epidemiology 1.4



 
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Impact Factors of Nutrition and Obesity Journals

Below are 2005 journal IMPACT FACTORS for nutrition and obesity journals. Visit here for general science and general clinical journal impact factors.

Nutition/Obesity

Ann Rev Nutrition 8.6
Am J Clinical Nutrition 5.9
Int J Obesity 4.5
Obesity Research 4.0
Crit Rev Food Science 3.9
Obesity Surgery 3.8
J Nutrition 3.7
Curr Opin Clinical Nutrition 3.3
British J Nutrition 3.0
Proc Nutrition Soc 2.6
Diabetes Obesity and Metabolism 2.5
Nutrition Rev 2.5
J Am Diet Assoc 2.4
Nutrition and Cancer 2.4
Clinical Nutrition 2.3
Eur J Nutrition 2.3
J Am Coll Nutrition 2.2
Eur J Clinical Nutrition 2.2
Nutrition 2.1
Nutrition Res Review 2.1
Public Health Nutrition 1.9



 
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Impact Factors of Cancer Journals

Below are 2005 journal IMPACT FACTORS for cancer-related journals. Visit here for general science and general clinical journal impact factors.

Cancer

J National Cancer Institute 15.2
J Clinical Oncology 11.8
Lancet Oncology 7.9
Cancer Research 7.6
Carcinogenesis 5.1
Cancer 4.8
Int J Cancer 4.7
Cancer Epidemiology Biomarkers and Prevention 4.5



 
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Impact Factors of Diabetes Journals

Below are journal IMPACT FACTORS for diabetes-related journals. Visit here for general science and general clinical journal impact factors.

Diabetes

Diabetes 8.0
Diabetes Care 7.8
Diabetologia 5.3
Diab Medicine 2.7
Diabetes Obesity Metab 2.5
Diabetic Metab Research 2.5
Nutrition Metab Cardiovascular Diseases 1.5



 
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Impact Factors of Cardiovascular Journals

Below are 2005 journal IMPACT FACTORS for cardiovascular disease-related journals. Visit here for general science and general clinical journal impact factors.

Cardiovascular Diseases

Circulation 11.6
Blood 10.1
Circulation Research 9.4
J Am Coll Cardiology 9.2
Eur Heart J 7.3
ATVB 7.1
Hypertension 6.3
Stroke 5.9
Cardiovascular Research 5.3
J Hypertension 5.2
Atherosclerosis 3.8
Am Heart J 3.5
Am J Hypertension 3.5
Thromb Haemost 3.1
Am J Cardiology 3.0
Eur J Cardiov Prev R 2.3



 
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Monday, September 11, 2006

Journal Impact Factors in 2005

Impact Factors for leading medical and science journals in 2005
(Source: ISI Journal Citation Reports impact factors tabulated from each journal's public website)

General (internal) medicine
  1. New England Journal of Medicine 44.0
  2. Nature Medicine 28.9
  3. Lancet 23.4
  4. Journal of the American Medical Association 23.3
  5. Annals of Internal Medicine 13.3
  6. British Medical Journal 9.0
  7. Archives of Internal Medicine 8.0
  8. Can Medical Assoc J 7.4
  9. Medicine 5.0
  10. Am J Medicine 4.4
  11. J Intern Medicine 4.0

General Science

  1. Science 30.9
  2. Cell 29.4
  3. Nature 29.3
  4. J Clinical Invest 15.1
  5. Plos Biol 14.7
  6. PNAS 10.3
  7. J Clinical Endocrin Metab 6.0
  8. Metabolism 2.3


Additional journal impact factors:

--> Impact Factors of Genetics journals

--> Impact Factors of Cancer journals

--> Impact Factors of Cardiovascular disease journals

--> Impact Factors of Diabetes journals

--> Impact Factors of Epidemiology and Public Health journals

--> Impact Factors of Nutrition and Obesity journals



 
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Monday, March 20, 2006

The Impact of Pre-Publication Presentation of Results: Epi Inquiry Accolade 03/20/2006

[Epidemiologic Inquiry 2006, 1: 21]

When is it a good idea, and when is it a bad idea to announce scientific results before formal publication? Does the medical community and the public quickly adopt pre-publication findings even though the results are not yet peer-reviewed? Such were the questions address by the recent article in JNCI by Giordano et al. and its accompanying editorial by Woloshin and Schwartz.

Giordano et al. investigated whether a new taxane treatment for lymph-node positive breast cancer significantly increased after its efficacy results were reported at the May 1998 meeting of the American Society of Clinical Oncology. Even though the taxane was not yet FDA approved and the formal publication was not to appear until 5 years later, the authors found that use of the newly reported treatment significantly increased >400% overall after the conference report. Furthermore, even though the treatment was shown only efficacious in lymph-node positive breast cancers (use increased 800%), results also showed that its use in patients with lymph-node negative breast cancers also increased 300%, which is in fact quite clinically disturbing as the drug was not even shown efficacious for such a disease.

The accompanying editorial by Woloshin and Schwartz summarized the risk and benefits of early adoption of pre-publication results, as well as noted examples in which early adoption has been clinically detrimental. Notably, the drug gefitinib (Iressa) had once been granted early FDA approval for increasing survival of patients with non-small-cell lung cancer who failed chemotherapy, even though the trial was unpublished, was a single uncontrolled trial, and subsequent issues were raised regarding adverse pneumonia deaths. Though over 200,000 people used the drug by 2004, a subsequent placebo-controlled trial shows no increased survival benefit. Such is an example in which adoption of pre-publication results did not benefit the public, and may have in fact caused more harm.

Woloshin and Schwartz summarize the following set of guideline regarding when to potentially adopt any pre-publication results:
1) large difference in all-cause mortality
2) no adverse effects
3) results are from a large randomized trial with long duration
4) confirms prior trial results, or presents first randomized trial evidence
5) no alternative treatments exist

For highlighting such important issues, the editors select as the dual-Epidemiologic Inquiry Accolade: Investigation of the Week...

Giordano SH, Duan Z, Kuo YF, Hortobagyi GN, Freeman J, Goodwin JS. Impact of a scientific presentation on community treatment patterns for primary breast cancer. J Natl Cancer Inst. 2006 Mar 15;98(6):382-8.

Woloshin S, Schwartz LM. What's the rush? The dissemination and adoption of preliminary research results. J Natl Cancer Inst. 2006 Mar 15;98(6):372-3.

~The Editors



 
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